Functional Analysis of Human Organic Cation Transporter OCT3 (SLC22A3) Polymorphisms
نویسندگان
چکیده
منابع مشابه
Pharmacology of Organic Cation Transporters: Focus on Structure-Function Relationships in OCT3 (SLC22A3)
5 GENERAL INTRODUCTION 7 MATERIALS AND METHODS 13 PART I: POLYAMINE TRANSPORT BY POLYSPECIFIC OCT1, OCT2, AND OCT3
متن کاملSynchronized activity of organic cation transporter 3 (Oct3/Slc22a3) and multidrug and toxin extrusion 1 (Mate1/Slc47a1) transporter in transplacental passage of MPP+ in rat.
The aim of the present study was to investigate the expression, localization, and function of organic cation transporter 3 (Oct3, Slc22a3) and multidrug and toxin extrusion protein 1 (Mate1, Slc47a1) in the rat placenta. Using qRT-PCR and Western blotting techniques, we demonstrated abundant Oct3 and Mate1 mRNA and protein expression achieving significantly higher levels than those in the mate...
متن کاملOrganic cation transporter 3 (Slc22a3) is implicated in salt-intake regulation.
Organic cation transporters (OCTs) are carrier-type permeases known to participate in general detoxification functions in peripheral tissues. Previous in vitro studies have suggested that OCTs ensure Uptake2, a low-affinity, corticosteroid-sensitive catecholamine removal system, which was characterized initially in sympathetically innervated tissues. Although the presence of both Uptake(2)-like...
متن کاملLoss of organic cation transporter 3 (Oct3) leads to enhanced proliferation and hepatocarcinogenesis
Background Organic cation transporters (OCT) are responsible for the uptake of a broad spectrum of endogenous and exogenous substrates. Downregulation of OCT is frequently observed in human hepatocellular carcinoma (HCC) and is associated with a poor outcome. The aim of our current study was to elucidate the impact of OCT3 on hepatocarcinogenesis. Methods Transcriptional and functional loss o...
متن کاملStructure, function, and regional distribution of the organic cation transporter OCT3 in the kidney.
We examined in this study the expression of the potential-sensitive organic cation transporter OCT3 in the kidney. A functionally active OCT3 was cloned from a mouse kidney cDNA library. The cloned transporter was found to be capable of mediating potential-dependent transport of a variety of organic cations including tetraethylammonium. This function was confirmed in two different heterologous ...
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ژورنال
عنوان ژورنال: Journal of Pharmacological Sciences
سال: 2010
ISSN: 1347-8613,1347-8648
DOI: 10.1254/jphs.09331sc